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Journal Article by M. Caroll, J. Newman, and J. Thorne: Effects of Menstrual Cycle Phase and PCP in Rhesus Monkeys
Effects of menstrual cycle phase on the reinforcing effects of
phencyclidine (PCP) in rhesus monkeys The publisher's final edited version of this article
is available at Pharmacol Biochem Behav. Abstract Oral self-administration of several concentrations of PCP (0.125, 0.25, and 0.5 mg/ml) was examined in three sexually mature female monkeys during 3-h experimental sessions. Menstrual cycle phase was determined by onset of menses, and verified by examining vaginal cytology. Overall, PCP self-administration was greater during the luteal phase, which is normally characterized by high levels of progesterone and moderate levels of estrogen, than the follicular phase, when levels of estrogen are increasing and progesterone levels are low. When examined within each phase, numbers of PCP deliveries were highest during the mid-luteal phase, compared to the early and mid-follicular phases. No differences in self-administration were observed between early and mid-follicular phases, but a significant difference in PCP deliveries was found between mid- and late luteal phases at the lowest concentration of PCP tested. The results from this study suggest that PCP�s reinforcing effects in female monkeys differ as a function of menstrual cycle phase. Keywords: Menstrual cycle, Oral drug self-administration, Phencyclidine, Female, Rhesus Monkey Click here to read full article (PDF) See University of Minnesota for additional information. Return to Articles and Reports |
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