DoD Biomedical Research Database Search Results - 2007

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DoD Biomedical Research Database Search Results - 2007

Title: Electrophysiological, Behavioral And Genetic Indicators Of Cognitive Performance Deficits Associate With Sleep-Deprivation In Nonhuman Primates: Assessment & Prevention
Research Category: N4: Neural Science
FY: 2005 Funding (in dollars): 645,259
Primary Contact: Public Affairs Office
City: Arlington
State: VA
Zip: 22203-1714
Objective: The primary testing component of the project consists of a non human primate model which employs many-neuron recording techniques to assess changes in identified neural ensemble correlates of short-term memory and motor performance during sleep deprivation. Parallel assessment and identification of regional brain metabolic changes following sleep deprivation, utilizing Positron Emission Tomography (PET), will be conducted in the same nonhuman primates, providing a powerful complementary approach for determining key brain areas susceptible to change during sleep deprivation. The identification of genomic changes that accompany sleep deprivation in rodents, comparing these changes to the deleterious effects of stress. The latter component will serve as a basis for developing molecular/pharmacological agents that reduce these effects.
Approach: This research project will characterize attenuate and potentially alleviate the deleterious effects of sleep deprivation in non human primates engaged in tasks requiring precise motor responses based on short-term memory. The Project will identify, in the same nonhuman primates, those brain regions that are altered during prolonged sleep deprivation, using sophisticated electrophysiological recording techniques coupled with non invasive imaging methods, and will provide the first complete description of genomic changes associated with long periods of sleep deprivation

Research was conducted in compliance with the Animal Welfare Act and other Federal statutes and regulations relating to the use of animals in research and was reviewed and approved by the Institute's Animal Care and Use Committee.

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