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Stop Animal
Exploitation NOW!
S. A. E. N.
"Exposing the truth to wipe
out animal experimentation"
Government Grants Promoting Cruelty to Animals
University of Michigan, Ann Arbor, MI
JAMES H. WOODS - Primate Testing - 2007
Grant Number: 5R01DA021416-02
Project Title: Development of Esterases for the Treatment of
Cocaine Overdose and Abuse
PI Information: PROFESSOR JAMES H. WOODS,
[email protected]
Abstract: DESCRIPTION (provided by applicant): Cocaine esterase (CocE)
is a product of the bacterium Rhodococcus sp. which grows in the
rhizosphere of coca plants in South America. The bacterium uses cocaine
as its sole source of carbon and nitrogen, synthesizing CocE to initiate
metabolism of the cocaine CocE is the most efficient enzyme (7.2 X 108)
for metabolizing cocaine yet identified. It can both prevent and reverse
extreme cocaine toxicity in our rodent models, and it has the potential
to be developed into the first useful antagonist of cocaine's toxic
effects. This proposal contains studies to continue to evaluate this
enzyme in mouse and rat models of cocaine toxicity, to compare its
effects with other protein-based anti-cocaine enzymes, and to use a
variety of in vitro techniques, including pegylation and insertion into
red blood cells, to improve this or other enzymes by reducing their
antigenicity, and heat liability. These procedures are designed to
prolong the enzyme's duration of action with the hopeful outcome that
some insight will be obtained into how to make this substance useful in
the long-term treatment of cocaine abuse.
Thesaurus Terms:
There are no thesaurus terms on file for this project.
Institution: UNIVERSITY OF MICHIGAN AT ANN ARBOR
3003 SOUTH STATE STREET, Room 1040
ANN ARBOR, MI 48109
Fiscal Year: 2007
Department: PHARMACOLOGY
Project Start: 10-MAY-2006
Project End: 30-APR-2010
ICD: NATIONAL INSTITUTE ON DRUG ABUSE
IRG: NIDA |
Please email: JAMES H. WOODS,
[email protected]
to protest the inhumane use of animals in this
experiment. We would also love to know about your efforts with this
cause:
[email protected]
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Rats, mice, birds, amphibians and other animals have
been excluded from coverage by the Animal Welfare Act. Therefore research
facility reports do not include these animals. As a result of this
situation, a blank report, or one with few animals listed, does not mean
that a facility has not performed experiments on non-reportable animals. A
blank form does mean that the facility in question has not used covered
animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs,
sheep, goats, etc.). Rats and mice alone are believed to comprise over 90%
of the animals used in experimentation. Therefore the majority of animals
used at research facilities are not even counted.
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