Air Force Research Labs, Brooks Air Force Base, TX
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Air Force Research Labs, Brooks Air Force Base,
TX DOD Funding of Animal Cruelty 2005: Research Category: N1: Physical Protection FY: 2005 Funding (in dollars): $520,356 Responsible Organization: AIR FORCE RESEARCH LAB/BROOKS Keywords: LABORATORY ANIMALS RETINA EYE LASER INJURY Objective: To collect retinal damage threshold data and to
examine the pathology of retinal tissues in cynomolgus monkeys under
selected laser exposure conditions for which the analogous
determinations have already been conducted in the rhesus monkey. To
ascertain via these ?bridging? studies whether or not the Cynomolgus
monkey would be a suitable alternative to the rhesus for future studies.
Approach: The great majority of the experimental data base
upon which DOD and national laser safety standards are based, consists
of ED50 damage thresholds obtained using the rhesus monkey (Macaca
mulatta) as an animal model. Due to the increased need by the
human/simian retrovirus research community, in the investigation of
AIDS, Indian Origin Rhesus Monkeys have become extremely difficult to
obtain. This protocol is proposed as the first of a series of ?bridging?
studies which is collecting retinal damage threshold data from an
alternative primate model ? the Cynomolgus (Macaca fascicularis) whose
projected availability and cost could alleviate the problems associated
with the continued use of rhesus subjects for such studies. The
experiments are structured in such a way as to continue to collect
limited threshold and damage mechanism data pertinent to laser safety
standard issues from the few available rhesus, while replicating the
experiments for several key laser exposure parameters in the Cynomolgus.
The protocol is extending the studies of new damage mechanisms and
multiple-pulse cumulative effects by assessing multiple-pulse (single
pulse to 30 kHz) damage thresholds for trains of 5 nsec, 1064 um pulses.
The nature of the additivity of multiple-pulse exposures will be
contrasted with published results and safety standard treatments for
repetitive-pulse exposures (for comparable wavelength and pulse
repetition frequencies). Research was conducted in compliance with the Animal Welfare Act and
other Federal statutes and regulations relating to the use of animals in
research and was reviewed and approved by the Institute's Animal Care
and Use Committee.
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