Air Force Research Labs, Brooks Air Force Base, TX
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Air Force Research Labs, Brooks Air Force Base,
TX DOD Funding of Animal Cruelty 2005: Research Category: FY: 2005 Funding (in dollars): $395,000 Responsible Organization: AIR FORCE RESEARCH LAB/BROOKS Keywords: LABORATORY ANIMALS LASER BIOEFFECTS OPTICAL LIMITER
OCULAR INJURY Objective: Optical limiters are capable of protecting against
pulsed laser sources without seriously degrading visual performance. The
USAF has conducted laboratory and field performance testing on a
prototype optical sight with an optical limiter designated the Direct
View Goggle (DVG). The laser energy transmitted to the eye is less than
that typically required to damage the eye. The objective of this work is
to measure the laser protection provided by the DVG device in monkey
trials with pulsed laser radiation. These animal-use trials are critical
for Air Force acceptance and advanced development of the DVG device. Approach: This study will produce dose-response data for the
production of laser-induced macular and paramacular retinal damage in
rhesus monkeys protected by the DVG device. Six anesthetized monkeys
fitted with the DVG device will receive 15 exposures in each eye to
single pulses of 532 nm, Q-switched, laser energy. The on-axis, incident
laser beam will be expanded and collimated to overfill the DVG input
objective. The incident energy will be the experimental variable for
determining the minimum visible lesion threshold and will be varied from
~1 ?YJ to a maximum of 10 mJ. The incident energy will be recorded for
each exposure. The presence or absence of retinal alteration at each
exposure site will be determined via ophthalmoscopic examination at one
hour post exposure and at 24 hours post exposure and correlated to the
dose at that site. Research was conducted in compliance with the Animal Welfare Act and
other Federal statutes and regulations relating to the use of animals in
research and was reviewed and approved by the Institute's Animal Care
and Use Committee.
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